Digestive PEComas: a solution when the diagnosis fails to "fit"

Details

Serval ID
serval:BIB_049A0ED614BC
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Digestive PEComas: a solution when the diagnosis fails to "fit"
Journal
Annals of Diagnostic Pathology
Author(s)
Genevay  M., Mc  K. T., Zimmer  G., Cathomas  G., Guillou  L.
ISSN
1092-9134 (Print)
Publication state
Published
Issued date
2004
Volume
8
Number
6
Pages
367-372
Notes
PT - Case Reports PT - Journal Article
Abstract
We report two cases of digestive/intra-abdominal PEComa. The first lesion developed in the caecum of a 36-year-old woman, the second in the pararectal region of a 35-year-old woman. The first tumor was formed from spindle cells arranged in fascicles, the second contained predominantly epithelioid cells with prominent nucleoli. Immunohistochemically, tumor cells expressed smooth muscle actin and melanocyte markers (HMB45), S-100 protein and CD117 were negative. Based on the morphologic aspect and, above all, on the immunohistochemical study the diagnosis of PEComa was retained for both lesions. In the gastrointestinal tract, the principal differential diagnoses of PEComas are gastrointestinal stromal tumors, particularly the round cell/epithelioid subtype, and metastases of carcinoma and melanoma. Other differential diagnoses include rhabdomyosarcoma, paraganglioma, leiomyosarcoma, and clear cell sarcoma
Keywords
Abdominal Neoplasms/chemistry/diagnosis/surgery/Adult/Angiomyolipoma/Carcinoma/secondary/Diagnosis,Differential/Epithelioid Cells/Pathology/Female/Gastrointestinal Stromal Tumors/Humans/Immunoenzyme Techniques/Melanoma/Neoplasm Proteins/Paraganglioma,Extra-Adrenal/Sarcoma/Tumor Markers,Biological/analysis
Pubmed
Create date
29/01/2008 18:36
Last modification date
20/08/2019 12:26
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