Phase II study of docetaxel alternating with cisplatin in chemotherapy-naive patients with advanced non-small cell lung cancer

Details

Serval ID
serval:BIB_0497A765F76C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Phase II study of docetaxel alternating with cisplatin in chemotherapy-naive patients with advanced non-small cell lung cancer
Journal
Anti-Cancer Drugs
Author(s)
Mattson  K., Vansteenkiste  J., Stupp  R., Bargetzi  M., Saarinen  A., Jekunen  A., Fillet  G., Teixeira  M., Gatzemeier  U., Olivares  R., Soussan-Lazard  K., Berille  J.
ISSN
0959-4973 (Print)
Publication state
Published
Issued date
01/2000
Volume
11
Number
1
Pages
7-13
Notes
Clinical Trial
Clinical Trial, Phase II
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
The objective of this study was to evaluate a regimen of full doses of docetaxel and cisplatin, using an alternating schedule, as first-line therapy for patients with inoperable non-small cell lung cancer (NSCLC). The standard concomitant schedule does not allow full doses of both drugs to be administered. We wanted to see if there was an advantage to be gained by administering full doses of both docetaxel and cisplatin, using a different schedule. Docetaxel 100 mg/m2 was given once every 6 weeks from week 1 and cisplatin (120 mg/m2 for two doses and 100 mg/m2 thereafter) once every 6 weeks from week 4, for six cycles (three docetaxel and three cisplatin). Thirty-six of the 44 patients enrolled were evaluable for efficacy. Forty-eight percent of the patients had good (KPS 90-100%) performance status. A median of five cycles was administered, for which no dose reductions were necessary. There were 13 of 36 partial responses (36%; 95% CI 21-54%) and 15 of 36 patients achieved stable disease (42%). The median duration of response was 10.5 months, the median time to progression was 4.5 months and the median survival was 9 months. The 1 and 2 year survival rates were 39 and 16%, respectively. The most frequent grade 3-4 toxicities were nausea (23% of patients), vomiting (18%) and neutropenia (77%). Infections were also common, but not severe. The alternating schedule produced response, toxicity and survival figures that compared favorable with those using the concomitant schedule. This study could serve as a model for future studies of non-cisplatin-containing regimens, in which full doses of docetaxel could alternate with full doses of other new agents active against NSCLC.
Keywords
Adult Aged Antineoplastic Agents, Phytogenic/administration & dosage/adverse effects/therapeutic use Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use Carcinoma, Non-Small-Cell Lung/*drug therapy Cisplatin/administration & dosage/adverse effects/*therapeutic use Drug Administration Schedule Female Humans Lung Neoplasms/*drug therapy Male Middle Aged Paclitaxel/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use *Taxoids Treatment Outcome
Pubmed
Web of science
Create date
28/01/2008 8:39
Last modification date
20/08/2019 12:26
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