Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County.

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State: Public
Version: Final published version
Serval ID
serval:BIB_0457C3D9B12E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County.
Journal
BMC Infectious Diseases
Author(s)
Sarivalasis A., Zellweger J.P., Faouzi M., Daher O., Deslarzes C., Bodenmann P.
ISSN
1471-2334 (Electronic)
ISSN-L
1471-2334
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
12
Number
1
Pages
285
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
BACKGROUND: Screening and treatment of latent tuberculosis infection (LTBI) in asylum seekers (AS) may prevent future cases of tuberculosis. As the screening with Interferon Gamma Release Assay (IGRA) is costly, the objective of this study was to assess which factors were associated with LTBI and to define a score allowing the selection of AS with the highest risk of LTBI.
METHODS: In across-sectional study, AS seekers recently arrived in Vaud County, after screening for tuberculosis at the border were offered screening for LTBI with T-SPOT.TB and questionnaire on potentially risk factors. The factors associated with LTBI were analyzed by univariate and multivariate regression.
RESULTS: Among 393 adult AS, 98 (24.93%) had a positive IGRA response, five of them with active tuberculosis previously undetected. Six factors associated with LTBI were identified in multivariate analysis: origin, travel conditions, marital status, cough, age and prior TB exposure. Their combination leads to a robust LTBI predictive score.
CONCLUSIONS: The prevalence of LTBI and active tuberculosis in AS is high. A predictive score integrating six factors could identify the asylum seekers with the highest risk for LTBI.
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2013 11:04
Last modification date
20/08/2019 13:26
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