Atrial natriuretic peptides: reproducibility of renal effects and response of liver blood flow.

Details

Serval ID
serval:BIB_043C32AE32F3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Atrial natriuretic peptides: reproducibility of renal effects and response of liver blood flow.
Journal
European journal of clinical pharmacology
Author(s)
Biollaz J., Waeber B., Nussberger J., Porchet M., Brunner-Ferber F., Otterbein E.S., Gomez H.J., Brunner H.R.
ISSN
0031-6970
Publication state
Published
Issued date
1986
Peer-reviewed
Oui
Volume
31
Number
1
Pages
1-8
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
To assess the variability of the response to exogenous atrial natriuretic peptide (ANP), it was infused at the rate of 1 microgram/min for 2 h in 6 salt-loaded normal volunteers under controlled conditions on 2 occasions at an interval of 1 week. The effect on solute excretion and the haemodynamic and endocrine actions were highly reproducible. The constant ANP infusion caused a delayed and prolonged excretion of sodium, chloride and calcium, no change in potassium or phosphate excretion or in glomerular filtration rate but a marked decrease in renal plasma flow. Blood pressure, heart rate and the plasma levels of angiotensin II, aldosterone, arginine vasopressin and plasma renin activity were unaltered. The effect of a 2-h infusion of ANP 0.5 microgram/min or its vehicle on apparent hepatic blood flow (HBF) was also studied in 14 normal volunteers by measuring the indocyanine green clearance. A 21% decrease in HBF was observed in subjects who received the ANP infusion (p less than 0.01 vs vehicle). Thus, ANP infused at a dose that did not lower blood pressure decreased both renal and liver blood flow in normotensive volunteers. The renal and endocrine responses to ANP were reproducible over a 1-week interval.
Keywords
Adult, Atrial Natriuretic Factor, Blood Pressure, Electrolytes, Glomerular Filtration Rate, Heart Rate, Hormones, Humans, Kidney, Liver Circulation, Male, Renal Circulation
Pubmed
Web of science
Create date
05/03/2008 17:41
Last modification date
20/08/2019 13:26
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