Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial

Details

Serval ID
serval:BIB_03FB75C08867
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial
Journal
Intensive Care Medicine
Author(s)
Berger  M. M., Reymond  M. J., Shenkin  A., Rey  F., Wardle  C., Cayeux  C., Schindler  C., Chiolero  R. L.
ISSN
0342-4642
Publication state
Published
Issued date
01/2001
Peer-reviewed
Oui
Volume
27
Number
1
Pages
91-100
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jan
Abstract
OBJECTIVE: To investigate whether early selenium (Se) supplementation can modify the post-traumatic alterations of thyroid hormone metabolism, since the first week after trauma is characterised by low plasma Se and negative Se balances. DESIGN: Prospective, placebo-controlled randomised supplementation trial. SETTING: Surgical ICU in a tertiary university hospital. PATIENTS: Thirty-one critically ill trauma patients aged 42 +/- 16 years (mean +/- SD), with severe multiple injury (Injury Severity Score 30 +/- 7). INTERVENTION: Supplementation during the first 5 days after injury with either Se or placebo. The selenium group was further randomised to receive daily 500 microg Se, with or without 150 mg alpha-tocopherol (AT) and 13 mg zinc supplements. The placebo group received the vehicle. Circulating Se, AT, zinc, and thyroid hormones were determined on D0 (= day 0, admission), D1, D2, D5, D10, and D20. RESULTS: Plasma Se, low on D0, normalised from D1 in the selenium group; total T4 and T3 increased more and faster after D2 (P = 0.04 and 0.08), reverse T3 rising less between D0 and D2 (P = 0.05). CONCLUSIONS: Selenium supplements increased the circulating Se levels. Supplementation was associated with modest changes in thyroid hormones, with an earlier normalisation of T4 and reverse T3 plasma levels. The addition of AT and zinc did not produce any additional change.
Keywords
Adult Analysis of Variance Antioxidants/therapeutic use Drug Therapy, Combination Euthyroid Sick Syndromes/etiology/*prevention & control Humans Prospective Studies Selenium/*deficiency/*therapeutic use Thyroxine/blood Triiodothyronine, Reverse/blood Vitamin E/therapeutic use Wounds and Injuries/blood/complications/*drug therapy Zinc/therapeutic use
Pubmed
Web of science
Create date
11/02/2008 14:11
Last modification date
20/08/2019 12:25
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