Functional differentiation of tbf1 orthologues in fission and budding yeasts.

Details

Serval ID
serval:BIB_03EFE0266E48
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional differentiation of tbf1 orthologues in fission and budding yeasts.
Journal
Eukaryotic Cell
Author(s)
Cockell M.M., Lo Presti L., Cerutti L., Cano Del Rosario E., Hauser P.M., Simanis V.
ISSN
1535-9786[electronic]
Publication state
Published
Issued date
2009
Volume
8
Number
2
Pages
207-216
Language
english
Abstract
In Saccharomyces cerevisiae, TBF1, an essential gene, influences telomere function but also has other roles in the global regulation of transcription. We have identified a new member of the tbf1 gene family in the mammalian pathogen Pneumocystis carinii. We demonstrate by transspecies complementation that its ectopic expression can provide the essential functions of Schizosaccharomyces pombe tbf1 but that there is no rescue between fission and budding yeast orthologues. Our findings indicate that an essential function of this family of proteins has diverged in the budding and fission yeasts and suggest that effects on telomere length or structure are not the primary cause of inviability in S. pombe tbf1 null strains.
Keywords
Amino Acid Sequence, Cell Nucleus/genetics, Cell Nucleus/metabolism, Chromatin/chemistry, Chromatin/metabolism, DNA-Binding Proteins/chemistry, DNA-Binding Proteins/genetics, Fungal Proteins/chemistry, Fungal Proteins/genetics, Genetic Complementation Test, Molecular Sequence Data, Phenotype, Pneumocystis carinii/chemistry, Pneumocystis carinii/genetics, Saccharomyces cerevisiae Proteins/chemistry, Saccharomyces cerevisiae Proteins/genetics, Saccharomycetales/chemistry, Saccharomycetales/genetics, Schizosaccharomyces/chemistry, Schizosaccharomyces/genetics, Schizosaccharomyces pombe Proteins/chemistry, Schizosaccharomyces pombe Proteins/genetics, Sequence Homology, Amino Acid, Telomere/chemistry, Telomere/metabolism, Transcription Factors
Pubmed
Web of science
Open Access
Yes
Create date
09/02/2010 9:15
Last modification date
20/08/2019 12:25
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