Metabolic and respiratory effects of infused sodium acetate in healthy human subjects.

Details

Serval ID
serval:BIB_03E8C62FB99F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic and respiratory effects of infused sodium acetate in healthy human subjects.
Journal
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
Author(s)
Burnier P., Tappy L., Jéquier E., Schneeberger D., Chioléro R.
ISSN
0363-6119 (Print)
ISSN-L
0002-9513
Publication state
Published
Issued date
1992
Volume
263
Number
6 Pt 2
Pages
R1271-R1276
Language
english
Abstract
The metabolic and respiratory effects of intravenous 0.5 M sodium acetate (at a rate of 2.5 mmol/min during 120 min) were studied in nine normal human subjects. O2 consumption (VO2) and CO2 production (VCO2) were measured continuously by open-circuit indirect calorimetry. VO2 increased from 251 +/- 9 to 281 +/- 9 ml/min (P < 0.001), energy expenditure increased from 4.95 +/- 0.17 kJ/min baseline to 5.58 +/- 0.16 kJ/min (P < 0.001), and VCO2 decreased nonsignificantly (211 +/- 7 ml/min vs. 202 +/- 7 ml/min, NS). The extrapulmonary CO2 loss (i.e., bicarbonate generation and excretion) was estimated at 48 +/- 5 ml/min. This observation is consistent with 1 mol of bicarbonate generated from 1 mol of acetate metabolized. Alveolar ventilation decreased from 3.5 +/- 0.2 l/min basal to 3.1 +/- 0.2 l/min (P < 0.001). The minute ventilation (VE) to VO2 ratio decreased from 22.9 +/- 1.3 to 17.6 +/- 0.9 l/l (P < 0.005), arterial PO2 decreased from 93.2 +/- 1.9 to 78.7 +/- 1.6 mmHg (P < 0.0001), arterial PCO2 increased from 39.2 +/- 0.7 to 42.1 +/- 1.1 mmHg (P < 0.0001), pH from 7.40 +/- 0.005 to 7.50 +/- 0.007 (P < 0.005), and arterial bicarbonate concentration from 24.2 +/- 0.7 to 32.9 +/- 1.1 (P < 0.0001). These observations indicate that sodium acetate infusion results in substantial extrapulmonary CO2 loss, which leads to a relative decrease of total and alveolar ventilation.
Keywords
Acetates/pharmacology, Acetic Acid, Adult, Bicarbonates/metabolism, Fatty Acids, Nonesterified/blood, Female, Hemodynamics/drug effects, Humans, Infusions, Intravenous, Male, Metabolism/drug effects, Oxidation-Reduction/drug effects, Pulmonary Gas Exchange/drug effects, Reference Values, Respiration/drug effects
Pubmed
Web of science
Create date
24/01/2008 13:36
Last modification date
20/08/2019 12:25
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