Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects.

Details

Serval ID
serval:BIB_03CE9B0DBFDE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects.
Journal
Journal of Pharmacology and Experimental Therapeutics
Author(s)
Schmid Y., Rickli A., Schaffner A., Duthaler U., Grouzmann E., Hysek C.M., Liechti M.E.
ISSN
1521-0103 (Electronic)
ISSN-L
0022-3565
Publication state
Published
Issued date
2015
Volume
353
Number
1
Pages
102-111
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a popular recreational drug. The aim of the present study was to explore the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the dopamine and norepinephrine transporters through which MDMA releases dopamine and norepinephrine by investigating. The pharmacodynamic and pharmacokinetic interactions between bupropion and MDMA in 16 healthy subjects were investigated using a double-blind, placebo-controlled, crossover design. Bupropion reduced the MDMA-induced elevations in plasma norepinephrine concentrations and the heart rate response to MDMA. In contrast, bupropion increased plasma MDMA concentrations and prolonged its subjective effects. Conversely, MDMA increased plasma bupropion concentrations. These results indicate a role for the transporter-mediated release of norepinephrine in the cardiostimulant effects of MDMA but do not support a modulatory role for dopamine in the mood effects of MDMA. These results also indicate that the use of MDMA during therapy with bupropion may result in higher plasma concentrations of both MDMA and bupropion and enhanced mood effects but also result in lower cardiac stimulation.
Keywords
Adult, Bupropion/pharmacokinetics, Bupropion/pharmacology, Cross-Over Studies, Dopamine/blood, Dopamine Plasma Membrane Transport Proteins/metabolism, Double-Blind Method, Drug Interactions, Epinephrine/blood, Female, Heart Rate/drug effects, Humans, Hydrocortisone/blood, Male, N-Methyl-3,4-methylenedioxyamphetamine/pharmacokinetics, N-Methyl-3,4-methylenedioxyamphetamine/pharmacology, Norepinephrine Plasma Membrane Transport Proteins/metabolism, Oxytocin/blood, Prolactin/blood, Psychotropic Drugs/pharmacokinetics, Psychotropic Drugs/pharmacology, Young Adult
Pubmed
Open Access
Yes
Create date
09/02/2016 14:14
Last modification date
20/08/2019 12:25
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