Rapid Effects of Selection on Brain-wide Activity and Behavior.
Details
Serval ID
serval:BIB_03C4C5E7B5FD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Rapid Effects of Selection on Brain-wide Activity and Behavior.
Journal
Current biology
ISSN
1879-0445 (Electronic)
ISSN-L
0960-9822
Publication state
Published
Issued date
21/09/2020
Peer-reviewed
Oui
Volume
30
Number
18
Pages
3647-3656.e3
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Interindividual variation in behavior and brain activity is universal and provides substrates for natural selection [1-9]. Selective pressures shift the expression of behavioral traits at the population level [10, 11], but the accompanying changes of the underlying neural circuitry have rarely been identified [12, 13]. Selection likely acts through the genetic and/or epigenetic underpinnings of neural activity controlling the selected behavior [14]. Endocrine and neuromodulatory systems participate in behavioral diversity and could provide the substrate for evolutionary modifications [15-21]. Here, we examined brain-wide patterns of activity in larval zebrafish selectively bred over two generations for extreme differences in habituation of the acoustic startle response (ASR) [22]. The ASR is an evolutionarily conserved defensive behavior induced by strong acoustic/vibrational stimuli. ASR habituation shows great individual variability that is stable over days and heritable [4, 22]. Selection for high ASR habituation leads to stronger sound-evoked activation of ASR-processing brain areas. In contrast, animals selected for low habituation displayed stronger spontaneous activity in ASR-processing centers. Ablation of dopaminergic tyrosine hydroxylase (TH) neurons decreased ASR sensitivity. Independently selected ASR habituation lineages link the effect of behavioral selection to dopaminergic caudal hypothalamus (HC) neurons [23]. High ASR habituation co-segregated with decreased spontaneous swimming phenotypes, but visual startle responses were unaffected. Furthermore, high- and low-habituation larvae differed in stress responses as adults. Thus, selective pressure over a couple of generations on ASR habituation behavior is able to induce substantial differences in brain activity, carrying along additional behaviors as piggyback traits that might further affect fitness in the wild. VIDEO ABSTRACT.
Keywords
Acoustic Stimulation, Animals, Brain/physiology, Dopaminergic Neurons/cytology, Dopaminergic Neurons/physiology, Habituation, Psychophysiologic, Hypothalamus/cytology, Hypothalamus/physiology, Larva/physiology, Nervous System Physiological Phenomena, Reflex, Startle, Zebrafish/physiology, behavioral selection, brain evolution, individuality, neuromodulation, startle, zebrafish
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2024 16:44
Last modification date
18/09/2024 11:45