Topology predicts long-term functional outcome in early psychosis.

Details

Ressource 1Download: Fournier et al. 2020.pdf (3464.86 [Ko])
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_03BB9CC4B9B3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Topology predicts long-term functional outcome in early psychosis.
Journal
Molecular psychiatry
Author(s)
Fournier M. (co-first), Scolamiero M. (co-first), Gholam-Rezaee M.M., Cleusix M., Jenni R., Ferrari C., Golay P., Baumann P.S., Cuenod M., Conus P. (co-last), Do K.Q. (co-last), Hess K. (co-last)
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Early intervention in psychosis is crucial to improving patient response to treatment and the functional deficits that critically affect their long-term quality of life. Stratification tools are needed to personalize functional deficit prevention strategies at an early stage. In the present study, we applied topological tools to analyze symptoms of early psychosis patients, and detected a clear stratification of the cohort into three groups. One of the groups had a significantly better psychosocial outcome than the others after a 3-year clinical follow-up. This group was characterized by a metabolic profile indicative of an activated antioxidant response, while that of the groups with poorer outcome was indicative of oxidative stress. We replicated in a second cohort the finding that the three distinct clinical profiles at baseline were associated with distinct outcomes at follow-up, thus validating the predictive value of this new stratification. This approach could assist in personalizing treatment strategies.
Pubmed
Open Access
Yes
Create date
22/06/2020 6:56
Last modification date
23/09/2020 5:24
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