Evaluation of compliance with isotretinoin PPP recommendations and exploration of reasons for non-compliance: Survey among French-speaking health care professionals and patients in Belgium.

Details

Serval ID
serval:BIB_03B87604B64A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of compliance with isotretinoin PPP recommendations and exploration of reasons for non-compliance: Survey among French-speaking health care professionals and patients in Belgium.
Journal
Pharmacoepidemiology and drug safety
Author(s)
Lelubre M., Hamdani J., Senterre C., Amighi K., Peres M., Schneider M.P., Bugnon O., De Vriese C.
ISSN
1099-1557 (Electronic)
ISSN-L
1053-8569
Publication state
Published
Issued date
06/2018
Peer-reviewed
Oui
Volume
27
Number
6
Pages
668-673
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To evaluate awareness of and compliance in Belgium by French-speaking health care professionals and patients with the isotretinoin safety recommendations regarding its teratogenic risk.
Survey using online questionnaires, delivered from December 2014 to March 2015 for patients, pharmacists, dermatologists, and GPs and delivered again from September 2015 to October 2015 for GPs.
Questionnaires were completed by 24 dermatologists, 24 GPs, 58 pharmacists, and 33 female patients. The pregnancy prevention programme was poorly known by health care professionals (23.6%) and patients (15.2%). Health care professionals informed women of childbearing age in depth about the teratogenic risk (98.3% of pharmacists and 100.0% of GPs and dermatologists) and the importance of an effective contraceptive method (87.9% and 100.0%, respectively). Patients were less informed about the pregnancy test (25.9% and 14.6%) and the need to use a second contraceptive method (29.3% and 27.1%). The low compliance with the last 2 recommendations was due to a lack of adoption by health care professionals regarding the need for these recommendations if female patients have an effective contraceptive method and the pregnancy risk is discussed in detail with them.
The effectiveness of the pregnancy prevention programme recommendations should be reconsidered by an expert committee. Justifications should be added to effective recommendations to increase their adoption by health care professionals and patients.
Keywords
Abnormalities, Drug-Induced/etiology, Abnormalities, Drug-Induced/prevention & control, Acne Vulgaris/drug therapy, Adolescent, Adult, Belgium, Contraception/standards, Contraception/statistics & numerical data, Dermatologic Agents/adverse effects, Dermatologists/statistics & numerical data, Female, Guideline Adherence/statistics & numerical data, Health Knowledge, Attitudes, Practice, Humans, Isotretinoin/adverse effects, Middle Aged, Patient Compliance/statistics & numerical data, Pharmacists/statistics & numerical data, Pregnancy, Pregnancy Complications/drug therapy, Surveys and Questionnaires/statistics & numerical data, Teratogens/toxicity, Young Adult, compliance, isotretinoin, patient safety, pharmacoepidemiology, pregnancy prevention programme, risk management plan
Pubmed
Web of science
Create date
12/05/2018 9:53
Last modification date
24/09/2019 5:11
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