NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma.

Details

Serval ID
serval:BIB_03A1F1D8B870
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma.
Journal
Immunology and Cell Biology
Author(s)
Chow M.T., Tschopp J., Möller A., Smyth M.J.
ISSN
1440-1711 (Electronic)
ISSN-L
0818-9641
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
90
Number
10
Pages
983-986
Language
english
Notes
Publication types: Journal Article
pdf: Short Communication
Abstract
Asbestos exposure can result in serious and frequently lethal diseases, including malignant mesothelioma. The host sensor for asbestos-induced inflammation is the NLRP3 inflammasome and it is widely assumed that this complex is essential for asbestos-induced cancers. Here, we report that acute interleukin-1β production and recruitment of immune cells into peritoneal cavity were significantly decreased in the NLRP3-deficient mice after the administration of asbestos. However, NLRP3-deficient mice displayed a similar incidence of malignant mesothelioma and survival times as wild-type mice. Thus, early inflammatory reactions triggered by asbestos are NLRP3-dependent, but NLRP3 is not critical in the chronic development of asbestos-induced mesothelioma. Notably, in a two-stage carcinogenesis-induced papilloma model, NLRP3-deficient mice showed a resistance phenotype in two different strain backgrounds, suggesting a tumour-promoting role of NLRP3 in certain chemically-induced cancer types.
Pubmed
Web of science
Create date
31/12/2012 13:16
Last modification date
20/08/2019 13:25
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