Presence and Persistence of Andes Virus RNA in Human Semen.

Details

Serval ID
serval:BIB_034CE3FBD3D4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Presence and Persistence of Andes Virus RNA in Human Semen.
Journal
Viruses
Author(s)
Züst R., Ackermann-Gäumann R., Liechti N., Siegrist D., Ryter S., Portmann J., Lenz N., Beuret C., Koller R., Staehelin C., Kuenzli A.B., Marschall J., Rothenberger S., Engler O.
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Publication state
Published
Issued date
17/11/2023
Peer-reviewed
Oui
Volume
15
Number
11
Pages
2266
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
When infecting humans, Andes orthohantavirus (ANDV) may cause a severe disease called hantavirus cardiopulmonary syndrome (HCPS). Following non-specific symptoms, the infection may progress to a syndrome of hemorrhagic fever combined with hyper-acute cardiopulmonary failure. The case fatality rate ranges between 25-40%, depending on the outbreak. In this study, we present the follow-up of a male patient who recovered from HCPS six years ago. We demonstrate that the ANDV genome persists within the reproductive tract for at least 71 months. Genome sequence analysis early and late after infection reveals a low number of mutations (two single nucleotide variants and one deletion), suggesting limited replication activity. We can exclude the integration of the viral genome into the host genome, since the treatment of the specimen with RNAse led to a loss of signal. We demonstrate a long-lasting, strong neutralizing antibody response using pseudovirions expressing the ANDV glycoprotein. Taken together, our results show that ANDV has the potential for sexual transmission.
Keywords
Humans, Male, Orthohantavirus/genetics, Semen, Antibodies, Neutralizing, RNA, Viral/genetics, Hantavirus Infections, Andes virus, neutralizing antibodies, persistence, semen
Pubmed
Web of science
Open Access
Yes
Create date
01/12/2023 11:10
Last modification date
23/12/2023 7:05
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