c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs.

Details

Serval ID
serval:BIB_0333000E22CD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs.
Journal
The Journal of experimental medicine
Author(s)
González-Loyola A., Bernier-Latmani J., Roci I., Wyss T., Langer J., Durot S., Munoz O., Prat-Luri B., Delorenzi M., Lutolf M.P., Zamboni N., Verdeil G., Petrova T.V.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Publication state
Published
Issued date
05/12/2022
Peer-reviewed
Oui
Volume
219
Number
12
Pages
e20212418
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Small intestinal villi are structural and functional units present in higher vertebrates and uniquely adapted to nutrient absorption. Villus enterocytes are organized in transcriptional "zones" dedicated to specialized tasks such as absorption of specific nutrients. We report that the transcription factor c-MAF is expressed in differentiated lower and mid-villus enterocytes and is a target of BMP signaling. Maf inactivation perturbed the villus zonation program by increasing carbohydrate-related transcripts while suppressing transcripts linked to amino-acid and lipid absorption. The formation of cytoplasmic lipid droplets, shuttling dietary fat to chylomicrons, was impaired upon Maf loss indicating its role in dietary lipid handling. Maf inactivation under homeostatic conditions expanded tuft cells and led to compensatory gut lengthening, preventing weight loss. However, delayed Maf-/- enterocyte maturation impaired weight recovery after acute intestinal injury, resulting in reduced survival. Our results identify c-MAF as a regulator of the intestinal villus zonation program, while highlighting the importance of coordination between stem/progenitor and differentiation programs for intestinal regeneration.
Keywords
Animals, Carbohydrates, Chylomicrons, Dietary Fats, Enterocytes, Nutrients, Transcription Factors
Pubmed
Create date
05/10/2022 7:59
Last modification date
14/10/2022 5:40
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