Human skin permeation rates ex vivo following exposures to mixtures of glycol ethers.

Details

Serval ID
serval:BIB_02FA1E4CA365
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human skin permeation rates ex vivo following exposures to mixtures of glycol ethers.
Journal
Toxicology letters
Author(s)
Berthet A., Oltramare C., Spring P., Hechon J., Hopf N.B.
ISSN
1879-3169 (Electronic)
ISSN-L
0378-4274
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Skin exposure to cleaning products in the general and occupational population are a public health concern. Among the most frequently identified amphiphilic organic solvents in cleaning products are propylene glycol monomethyl ether (PGME) and propylene glycol n-butyl ether (PGBE). Internal dose from skin exposure may be efficiently evaluated using in vitro flow-through diffusion cells with excised human skin. Our aim in this study was two-fold; 1) characterize the permeation rates (J), time lag (T <sub>lag</sub> ), and permeation coefficients (Kp) of PGME and PGBE in human ex-vivo skin permeation assays, and 2) determine a possible mixture effect on skin permeation characteristics when applied together. Our results showed a short T <sub>lag</sub> for PGME and was reduced further depending on the amount of PGBE in the mixture (T <sub>lag</sub> was reduced from 2 h to 1-1.7 h) for fresh skin. PGBE T <sub>lag</sub> slightly increased when mixed with 50% or more PGME. Permeation rate decreased to half for both PGME and PGBE in mixture at any concentration. This substantial permeation was greater with previously frozen skin. This mixture effect could favor permeation of other compounds through human skin.
Keywords
Human skin, Permeation, Mixture., Propylene glycol monomethyl ether (PGME), Propylene glycol n-butyl ether (PGBE)
Pubmed
Create date
09/10/2020 13:31
Last modification date
03/11/2020 6:22
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