The criminal association of Leishmania parasites and viruses.

Details

Serval ID
serval:BIB_02E69DE6AF21
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The criminal association of Leishmania parasites and viruses.
Journal
Current opinion in microbiology
Author(s)
Rossi M., Fasel N.
ISSN
1879-0364 (Electronic)
ISSN-L
1369-5274
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
46
Pages
65-72
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
In nature, humans infected with protozoan parasites can encounter viruses, which could alter their host immune response. The impact of viruses on human parasitic diseases remains largely unexplored due to the highly sterilized environment in experimental studies and the difficulty to draw a correlation between co-infection and pathology. Recent studies show that viral infections exacerbate pathology and promote dissemination of some Leishmania infections, based on a hyper-inflammatory reaction driven by type I interferons. Thus, not only the infecting parasite species, but also bystander viral infections could be a major determinant of the outcome of Leishmania infection. In this review, we focus on the contribution of viral co-infection to the exacerbation of leishmaniasis's pathology and its possible impact on treatment and vaccination strategies.
Keywords
Animals, Coinfection/parasitology, Coinfection/virology, Humans, Leishmania/genetics, Leishmania/physiology, Leishmaniasis/parasitology, Virus Diseases/virology, Virus Physiological Phenomena, Viruses/genetics
Pubmed
Web of science
Create date
20/08/2018 13:55
Last modification date
20/08/2019 13:25
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