Favourable effect of regular intake of fermented milk containing Lactobacillus johnsonii on Helicobacter pylori associated gastritis

Details

Serval ID
serval:BIB_02DBA30C9590
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Favourable effect of regular intake of fermented milk containing Lactobacillus johnsonii on Helicobacter pylori associated gastritis
Journal
Alimentary Pharmacology and Therapeutics
Author(s)
Pantoflickova  D., Corthesy-Theulaz  I., Dorta  G., Stolte  M., Isler  P., Rochat  F., Enslen  M., Blum  A. L.
ISSN
0269-2813 (Print)
Publication state
Published
Issued date
10/2003
Volume
18
Number
8
Pages
805-13
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Oct 15
Abstract
BACKGROUND: Lactobacillus johnsonii (Lj1) had an in vitro and in vivo inhibitory effect on Helicobacter pylori. Fermented milk containing Lj1 (LC1), coadministered with antibiotics had a favourable effect on H. pylori gastritis. AIM: Evaluate the effect of LC1 intake without antibiotics on H. pylori gastritis. METHODS: Fifty H. pylori positive healthy volunteers were randomised in a double-blind study to LC1 or placebo. Gastric biopsies from the antrum and corpus were obtained before, and after 3 and 16 weeks of treatment, for histology and quantitative cultures. RESULTS: Severity and activity of antral gastritis was reduced after 16-week LC1 intake (pretreatment and 16-week inflammatory cell score: 6.0 +/- 0.8 vs. 5.3 +/- 0.1; P=0.04). H. pylori density decreased in the antrum after LC1 intake (3-week: 4.4 +/- 0.6; 16-week: 4.3 +/- 0.5 log10 colony forming units (cfu) vs. pretreatment 4.5 +/- 0.4 log10 cfu; P=0.04, respectively). Mucus thickness increased after 16 weeks of LC1 consumption (change of mucus thickness with LC1 and placebo in the antrum: 0.6 +/- 1.3 vs. -0.2 +/- 1.0, P=0.01; in the corpus: 0.3 +/- 1.1 vs. -0.6 +/- 1.5, P=0.03). CONCLUSION: LC1 intake had a favourable, albeit weak, effect on H. pylori associated gastritis, particularly in the antrum. Regular ingestion of fermented milk containing L. johnsonii may reduce the risk of developing disorders associated with high degrees of gastric inflammation and mucus depletion.
Keywords
Adolescent Adult *Cultured Milk Products Defecation Double-Blind Method Female Flatulence Gastric Mucosa/microbiology Gastritis/diet therapy/*microbiology Helicobacter Infections/*diet therapy *Helicobacter pylori Humans *Lactobacillus Male Middle Aged Pyloric Antrum/microbiology
Pubmed
Web of science
Create date
25/01/2008 15:48
Last modification date
20/08/2019 12:24
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