Favourable effect of regular intake of fermented milk containing Lactobacillus johnsonii on Helicobacter pylori associated gastritis.

Details

Serval ID
serval:BIB_02DBA30C9590
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Favourable effect of regular intake of fermented milk containing Lactobacillus johnsonii on Helicobacter pylori associated gastritis.
Journal
Alimentary pharmacology & therapeutics
Author(s)
Pantoflickova D., Corthésy-Theulaz I., Dorta G., Stolte M., Isler P., Rochat F., Enslen M., Blum A.L.
ISSN
0269-2813 (Print)
ISSN-L
0269-2813
Publication state
Published
Issued date
15/10/2003
Peer-reviewed
Oui
Volume
18
Number
8
Pages
805-813
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Lactobacillus johnsonii (Lj1) had an in vitro and in vivo inhibitory effect on Helicobacter pylori. Fermented milk containing Lj1 (LC1), coadministered with antibiotics had a favourable effect on H. pylori gastritis.
Evaluate the effect of LC1 intake without antibiotics on H. pylori gastritis.
Fifty H. pylori positive healthy volunteers were randomised in a double-blind study to LC1 or placebo. Gastric biopsies from the antrum and corpus were obtained before, and after 3 and 16 weeks of treatment, for histology and quantitative cultures.
Severity and activity of antral gastritis was reduced after 16-week LC1 intake (pretreatment and 16-week inflammatory cell score: 6.0 +/- 0.8 vs. 5.3 +/- 0.1; P=0.04). H. pylori density decreased in the antrum after LC1 intake (3-week: 4.4 +/- 0.6; 16-week: 4.3 +/- 0.5 log10 colony forming units (cfu) vs. pretreatment 4.5 +/- 0.4 log10 cfu; P=0.04, respectively). Mucus thickness increased after 16 weeks of LC1 consumption (change of mucus thickness with LC1 and placebo in the antrum: 0.6 +/- 1.3 vs. -0.2 +/- 1.0, P=0.01; in the corpus: 0.3 +/- 1.1 vs. -0.6 +/- 1.5, P=0.03).
LC1 intake had a favourable, albeit weak, effect on H. pylori associated gastritis, particularly in the antrum. Regular ingestion of fermented milk containing L. johnsonii may reduce the risk of developing disorders associated with high degrees of gastric inflammation and mucus depletion.
Keywords
Adolescent, Adult, Cultured Milk Products, Defecation, Double-Blind Method, Female, Flatulence, Gastric Mucosa/microbiology, Gastritis/diet therapy, Gastritis/microbiology, Helicobacter Infections/diet therapy, Helicobacter pylori, Humans, Lactobacillus, Male, Middle Aged, Pyloric Antrum/microbiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:48
Last modification date
09/04/2024 7:13
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