Monocyte-derived dendritic cells can be detected in urine of kidney transplant recipients with pathogenic asymptomatic bacteriuria.
Details
Serval ID
serval:BIB_02C4EC74CB87
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Monocyte-derived dendritic cells can be detected in urine of kidney transplant recipients with pathogenic asymptomatic bacteriuria.
Journal
Frontiers in transplantation
ISSN
2813-2440 (Electronic)
ISSN-L
2813-2440
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Volume
3
Pages
1366104
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Urinary tract infections (UTI) are an important clinical problem in kidney transplant recipients (KTR). Asymptomatic bacteriuria (ASB) is frequent in these patients and often resolved by the immune system, but a significant proportion may progress to complicated UTI, which may compromise allograft function and survival. It is essential to determine the involvement of the immune system in the infectious process. Dendritic cells (DCs) are recognised as playing a pivotal role in initiating inflammatory responses capable of priming antigen-specific T cells, a crucial step in determining the fate of local inflammation. Little is known about their role in the control of UTI. In this brief communication, we report an incidental finding in a group of 16 stable KTR in which monocyte-derived dendritic cells (ModDCs), analysed by flow cytometry, were found in urine of patients with ASB and high bacterial counts >10 <sup>7</sup> cfu/ml. Within this group, one patient developed pyelonephritis in the following days. These findings suggest that the immune system, in particular DCs, may be recruited during the course of a UTI and, to our knowledge, present for the first time evidence that inflammatory ModDCs can be detected in urine. Their frequency may reflect the degree of infection. This finding suggests the potential for exploring whether these cells may be useful in distinguishing between pathogenic ASB and those that can be resolved by the immune system.
Keywords
UTI, asymptomatic bacteriuria, dendritic cells, kidney transplantation, monocyte-derived dendritic cell, urine
Pubmed
Open Access
Yes
Create date
19/07/2024 8:56
Last modification date
20/07/2024 7:07