Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes.

Details

Serval ID
serval:BIB_02A4AEE7F513
Type
Article: article from journal or magazin.
Collection
Publications
Title
Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Yang C.Y., Vogt T.K., Favre S., Scarpellino L., Huang H.Y., Tacchini-Cottier F., Luther S.A.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
2014
Volume
111
Number
1
Pages
E109-E118
Language
english
Abstract
Adaptive immunity is initiated in T-cell zones of secondary lymphoid organs. These zones are organized in a rigid 3D network of fibroblastic reticular cells (FRCs) that are a rich cytokine source. In response to lymph-borne antigens, draining lymph nodes (LNs) expand several folds in size, but the fate and role of the FRC network during immune response is not fully understood. Here we show that T-cell responses are accompanied by the rapid activation and growth of FRCs, leading to an expanded but similarly organized network of T-zone FRCs that maintains its vital function for lymphocyte trafficking and survival. In addition, new FRC-rich environments were observed in the expanded medullary cords. FRCs are activated within hours after the onset of inflammation in the periphery. Surprisingly, FRC expansion depends mainly on trapping of naïve lymphocytes that is induced by both migratory and resident dendritic cells. Inflammatory signals are not required as homeostatic T-cell proliferation was sufficient to trigger FRC expansion. Activated lymphocytes are also dispensable for this process, but can enhance the later growth phase. Thus, this study documents the surprising plasticity as well as the complex regulation of FRC networks allowing the rapid LN hyperplasia that is critical for mounting efficient adaptive immunity.
Keywords
lymph node swelling, fibroblasts, stromal cells, lymphotoxin, MyD88
Pubmed
Web of science
Open Access
Yes
Create date
14/01/2014 15:44
Last modification date
20/08/2019 13:24
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