Complement factors in adult peripheral nerve: a potential role in energy metabolism.

Details

Serval ID
serval:BIB_02A11E12C4CA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Complement factors in adult peripheral nerve: a potential role in energy metabolism.
Journal
Neurochemistry International
Author(s)
Chrast R., Verheijen M.H., Lemke G.
ISSN
0197-0186 (Print)
ISSN-L
0197-0186
Publication state
Published
Issued date
2004
Volume
45
Number
2-3
Pages
353-359
Language
english
Abstract
Complement cascade factors are known to play a critical role in myelin clearance after peripheral nerve injury. Here we show that components of both the classical (C1qa, C1qb, C1qc, C2 and C4) and alternative (C3, B and adipsin) pathways are expressed by uninjured peripheral nerve as well. mRNAs of components of the alternative pathway were predominantly found in the peri/epineurium, although factor C3 and factor B were also detected in the endoneurial compartment of adult nerve. Interestingly, adipsin mRNA was detected only in peri/epineurium, while adipsin protein was present in both peri/epineurium and endoneurium. This suggests that adipsin is transported to the endoneurium via the circulation from the peri/epineurium or outside of the nerve. Factor 5 and factor 9, necessary for the formation of the membrane-attack complex, were not detected in any part of the healthy peripheral nerve, which together with the observed presence of negative regulators of complement activation, is likely to prevent damage to the healthy nerve caused by complement activation. By analogy with the known role of complement factors in fat, we propose that local expression of these factors plays a role in the regulation of fatty acid homeostasis in the nerve and, thereby, in energy metabolism cross-talk between different compartments of the peripheral nerve.
Keywords
Adult, Animals, Complement Pathway, Alternative/genetics, Complement System Proteins/physiology, Energy Metabolism/physiology, Humans, In Situ Hybridization, Peripheral Nerves/growth & development, Peripheral Nerves/physiology, RNA, Messenger/genetics
Pubmed
Web of science
Create date
24/01/2008 14:12
Last modification date
20/08/2019 12:24
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