Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny.

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Serval ID
serval:BIB_028E66B5A84B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny.
Journal
Frontiers in Zoology
Author(s)
Scriba M.F., Ducrest A.L., Henry I., Vyssotski A.L., Rattenborg N.C., Roulin A.
ISSN
1742-9994 (Electronic)
ISSN-L
1742-9994
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
10
Number
1
Pages
42
Language
english
Abstract
BACKGROUND: Intra-specific variation in melanocyte pigmentation, common in the animal kingdom, has caught the eye of naturalists and biologists for centuries. In vertebrates, dark, eumelanin pigmentation is often genetically determined and associated with various behavioral and physiological traits, suggesting that the genes involved in melanism have far reaching pleiotropic effects. The mechanisms linking these traits remain poorly understood, and the potential involvement of developmental processes occurring in the brain early in life has not been investigated. We examined the ontogeny of rapid eye movement (REM) sleep, a state involved in brain development, in a wild population of barn owls (Tyto alba) exhibiting inter-individual variation in melanism and covarying traits. In addition to sleep, we measured melanistic feather spots and the expression of a gene in the feather follicles implicated in melanism (PCSK2).
RESULTS: As in mammals, REM sleep declined with age across a period of brain development in owlets. In addition, inter-individual variation in REM sleep around this developmental trajectory was predicted by variation in PCSK2 expression in the feather follicles, with individuals expressing higher levels exhibiting a more precocial pattern characterized by less REM sleep. Finally, PCSK2 expression was positively correlated with feather spotting.
CONCLUSIONS: We demonstrate that the pace of brain development, as reflected in age-related changes in REM sleep, covaries with the peripheral activation of the melanocortin system. Given its role in brain development, variation in nestling REM sleep may lead to variation in adult brain organization, and thereby contribute to the behavioral and physiological differences observed between adults expressing different degrees of melanism.
Keywords
REM sleep, Melanocortin, Melanism, Pleiotropy, Ontogeny, Development, Avian
Pubmed
Web of science
Open Access
Yes
Create date
28/08/2013 15:43
Last modification date
20/08/2019 13:24
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