New Delhi Metallo-β-Lactamase-Producing Enterobacterales Bacteria, Switzerland, 2019-2020.

Details

Serval ID
serval:BIB_01F4A49C5290
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
New Delhi Metallo-β-Lactamase-Producing Enterobacterales Bacteria, Switzerland, 2019-2020.
Journal
Emerging infectious diseases
Author(s)
Findlay J., Poirel L., Kessler J., Kronenberg A., Nordmann P.
ISSN
1080-6059 (Electronic)
ISSN-L
1080-6040
Publication state
Published
Issued date
10/2021
Peer-reviewed
Oui
Volume
27
Number
10
Pages
2628-2637
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Carbapenemase-producing Enterobacterales (CPE) bacteria are a critical global health concern; New Delhi metallo-β-lactamase (NDM) enzymes account for >25% of all CPE found in Switzerland. We characterized NDM-positive CPE submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance during a 2-year period (January 2019-December 2020) phenotypically and by using whole-genome sequencing. Most isolates were either Klebsiella pneumoniae (59/141) or Escherichia coli (52/141), and >50% were obtained from screening swabs. Among the 108 sequenced isolates, NDM-1 was the most prevalent variant, occurring in 56 isolates, mostly K. pneumoniae (34/56); the next most prevalent was NDM-5, which occurred in 49 isolates, mostly E. coli (40/49). Fourteen isolates coproduced a second carbapenemase, predominantly an OXA-48-like enzyme, and almost one third of isolates produced a 16S rRNA methylase conferring panresistance to aminoglycosides. We identified successful plasmids and global lineages as major factors contributing to the increasing prevalence of NDMs in Switzerland.
Keywords
Escherichia coli/enzymology, Escherichia coli/genetics, Klebsiella pneumoniae/enzymology, Klebsiella pneumoniae/genetics, Microbial Sensitivity Tests, RNA, Ribosomal, 16S, Switzerland/epidemiology, beta-Lactamases, Enterobacterales, Escherichia coli, Klebsiella pneumoniae, NDM, New Delhi metallo-β-lactamase, Switzerland, antimicrobial resistance, bacteria, carbapenemase, metallo-β-lactamase
Pubmed
Web of science
Open Access
Yes
Create date
23/05/2024 12:59
Last modification date
24/05/2024 7:05
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