Hepatitis B virus and hepatitis C virus infections in Belgium: similarities and differences in epidemics and initial management.

Details

Serval ID
serval:BIB_01F3EE9345BD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Hepatitis B virus and hepatitis C virus infections in Belgium: similarities and differences in epidemics and initial management.
Journal
European Journal of Gastroenterology and Hepatology
Author(s)
De Vroey B., Moreno C., Laleman W., van Gossum M., Colle I., de Galocsy C., Langlet P., Robaeys G., Orlent H., Michielsen P., Delwaide J., Reynaert H., D'Heygere F., Sprengers D., Bourgeois S., Assene C., Vos B., Brenard R., Adler M., Henrion J., Deltenre P.
ISSN
1473-5687 (Electronic)
ISSN-L
0954-691X
Publication state
Published
Issued date
2013
Volume
25
Number
5
Pages
613-619
Language
english
Notes
Publication types: Comparative Study ; Journal ArticlePublication Status: ppublish
Abstract
INTRODUCTION: Nationwide studies comparing patients with hepatitis B and C virus (HBV and HCV) infections are mandatory for assessing changes in epidemiology.
AIM: The aim of this study was to compare epidemiological data and initial management of newly diagnosed patients with persistent HBV (HBsAg positive) or HCV (detectable HCV RNA) infection in Belgium.
PATIENTS AND METHODS: Data were extracted from two Belgian observational databases.
RESULTS: A total of 655 patients (387 HBV and 268 HCV) were included. Compared with HCV patients, HBV patients were younger, more frequently men, more often of Asian or African origin (43 vs. 10%, P<0.0001), and less frequently contaminated by transfusion or intravenous drug use (9 and 6% vs. 34 and 44%, P<0.0001). Viral replication was assessed in 89% of HBV patients. Compared with HCV patients, HBV patients more frequently had normal alanine aminotransferase (ALT) levels (65 vs. 29%, P<0.0001), less frequently underwent liver biopsy (29 vs. 67%, P<0.0001), and were less often considered for antiviral therapy (25 vs. 54%, P<0.0001). When taking only HBV patients with detectable viral replication into consideration, results remained unchanged. During the multivariate analysis, ALT was a major factor for performing liver biopsy or considering antiviral therapy in both groups.
CONCLUSION: HBV and HCV screening policies should be targeted toward immigrants and intravenous drug users, respectively. Guidelines recommending systematic search for viral replication should be reinforced in HBV patients. HBV patients less frequently underwent liver biopsy and were less often considered for antiviral therapy compared with HCV patients. Despite the lack of sensitivity and specificity, ALT remains a pivotal decision-making tool for liver biopsy and antiviral therapy in both infections.
Keywords
Adult, Age Factors, Alanine Transaminase/blood, Antiviral Agents/therapeutic use, Belgium/epidemiology, Biological Markers/blood, Biopsy, Carrier State/epidemiology, Epidemics, Female, Hepatitis B/diagnosis, Hepatitis B/drug therapy, Hepatitis B Surface Antigens/blood, Hepatitis B virus/physiology, Hepatitis C/diagnosis, Hepatitis C/drug therapy, Humans, Liver/pathology, Male, Middle Aged, Registries, Risk Factors, Sex Factors, Viral Load, Virus Replication
Pubmed
Web of science
Create date
06/12/2013 10:02
Last modification date
20/08/2019 12:24
Usage data