A multidimensional model of memory complaints in older individuals and the associated hub regions.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_01E70EA8CB49
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A multidimensional model of memory complaints in older individuals and the associated hub regions.
Journal
Frontiers in aging neuroscience
Author(s)
Paban V., Mheich A., Spieser L., Sacher M.
ISSN
1663-4365 (Print)
ISSN-L
1663-4365
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Volume
15
Pages
1324309
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Memory complaints are highly prevalent among middle-aged and older adults, and they are frequently reported in individuals experiencing subjective cognitive decline (SCD). SCD has received increasing attention due to its implications for the early detection of dementia. This study aims to advance our comprehension of individuals with SCD by elucidating potential cognitive/psychologic-contributing factors and characterizing cerebral hubs within the brain network. To identify these potential contributing factors, a structural equation modeling approach was employed to investigate the relationships between various factors, such as metacognitive beliefs, personality, anxiety, depression, self-esteem, and resilience, and memory complaints. Our findings revealed that self-esteem and conscientiousness significantly influenced memory complaints. At the cerebral level, analysis of delta and theta electroencephalographic frequency bands recorded during rest was conducted to identify hub regions using a local centrality metric known as betweenness centrality. Notably, our study demonstrated that certain brain regions undergo changes in their hub roles in response to the pathology of SCD. Specifically, the inferior temporal gyrus and the left orbitofrontal area transition into hubs, while the dorsolateral prefrontal cortex and the middle temporal gyrus lose their hub function in the presence of SCD. This rewiring of the neural network may be interpreted as a compensatory response employed by the brain in response to SCD, wherein functional connectivity is maintained or restored by reallocating resources to other regions.
Keywords
cognitive factors, graph theory, memory complaints, structural equation modeling, subjective cognitive decline
Pubmed
Web of science
Open Access
Yes
Create date
12/01/2024 10:51
Last modification date
09/08/2024 15:55
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