Circulatory alterations induced by intra-arterial injection of iodized oil and emulsions of iodized oil and doxorubicin: experimental study.

Details

Serval ID
serval:BIB_017C4129B13B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Circulatory alterations induced by intra-arterial injection of iodized oil and emulsions of iodized oil and doxorubicin: experimental study.
Journal
Radiology
Author(s)
de Baere T., Dufaux J., Roche A., Counnord J.L., Berthault M.F., Denys A., Pappas P.
ISSN
0033-8419[print], 0033-8419[linking]
Publication state
Published
Issued date
1995
Volume
194
Number
1
Pages
165-170
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
PURPOSE: To evaluate circulatory alterations induced by intra-arterial injection of iodized oil and emulsions of iodized oil with an anticancer drug. MATERIALS AND METHODS: The viscosities and stability were evaluated in arterial flow of iodized oil and the emulsions. Doppler ultrasound was used to quantify the embolic effect in the arteries of rabbits. The behavior of doxorubicin and iodized oil in the rat cremaster muscle was studied with videomicroscopy. RESULTS: The emulsions did not break up after injection, and the size of discontinuous-phase droplets did not change. The embolic effect did not correlate with viscosity. The thinnest water-in-oil emulsion had the lowest embolic effect and induced homogeneous distribution of iodized oil droplets in the arterial tree. CONCLUSION: Changes in the formulation of emulsions obtained with the same proportions of drug and iodized oil change the distribution of iodized oil in the arterial tree, the location at which the drug is released, and the embolic effect.
Keywords
Abdominal Muscles/blood supply, Animals, Arteries/physiopathology, Blood Flow Velocity/drug effects, Chemoembolization, Therapeutic, Doxorubicin/administration & dosage, Doxorubicin/chemistry, Emulsions, Injections, Intra-Arterial, Iodized Oil/administration & dosage, Iodized Oil/chemistry, Microcirculation/drug effects, Rabbits, Rats, Viscosity/drug effects
Pubmed
Web of science
Create date
17/03/2010 10:40
Last modification date
20/08/2019 12:23
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