Co-selection of the rare T cell receptor-gamma B haplotype in mouse lines selected for low responsiveness to red blood cell antigens

Details

Serval ID
serval:BIB_016EDF9E13D8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Co-selection of the rare T cell receptor-gamma B haplotype in mouse lines selected for low responsiveness to red blood cell antigens
Journal
European Journal of Immunology
Author(s)
Roger  T., Pepin  L. F., Couderc  J., De Franco  M., Seman  M.
ISSN
0014-2980 (Print)
Publication state
Published
Issued date
01/1993
Volume
23
Number
1
Pages
287-90
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
T cell receptor (TcR)-gamma haplotype was investigated in seven pairs of murine Biozzi lines selected for low and high antibody (Ab) response to different antigens (Ag). High-responder lines (H) express gamma A or gamma C haplotypes irrespective of the selecting Ag. In contrast, the gamma B haplotype, which is rare in laboratory mouse strains, is found in all low-responder lines (L) to sheep erythrocyte Ag (SE). However, the TcR-gamma B locus might only have a low penetrance in the control of the SE response. Moreover, investigations using LIVA mice, which were selected for low SE response from homozygous gamma A founder parents, indicate that the gamma B haplotype is neither necessary nor sufficient to achieve a low-responder phenotype. The gamma B haplotype might, thus, be co-selected to confer to L mice an improved resistance to bacterial infections mediated by gamma delta T cells compensating the profound and nonspecific immune perturbation associated with the low Ab response.
Keywords
Animals Antibody Formation/*genetics Erythrocytes/*immunology *Haplotypes Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred DBA Polymorphism, Restriction Fragment Length Receptors, Antigen, T-Cell, alpha-beta/genetics Receptors, Antigen, T-Cell, gamma-delta/*genetics Sheep
Pubmed
Web of science
Create date
25/01/2008 14:35
Last modification date
20/08/2019 13:23
Usage data