Impact of 111In-DTPA-octreotide SPECT/CT fusion images in the management of neuroendocrine tumours.

Details

Serval ID
serval:BIB_016B83CBA50A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Impact of 111In-DTPA-octreotide SPECT/CT fusion images in the management of neuroendocrine tumours.
Journal
La Radiologia medica
Author(s)
Castaldi P., Rufini V., Treglia G., Bruno I., Perotti G., Stifano G., Barbaro B., Giordano A.
ISSN
0033-8362 (Print)
ISSN-L
0033-8362
Publication state
Published
Issued date
10/2008
Peer-reviewed
Oui
Volume
113
Number
7
Pages
1056-1067
Language
english italian
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article
Publication Status: ppublish
Abstract
Somatostatin receptor scintigraphy with [(111)In]-diethylene triamine pentaacetate acid (DTPA)-octreotide is an accurate method for detecting neuroendocrine tumours (NETs) but often does not provide clear anatomical localisation of lesions. The aim of this study was to assess the clinical usefulness of anatomical-functional image fusion.
Fifty-four patients with known or suspected NET were included in the study. Planar and single-photon-emission computed tomography (SPECT) imaging was performed using a dual-head gamma camera equipped with an integrated X-ray transmission system, and the images were first interpreted alone by two nuclear medicine physicians and then compared with SPECT/CT fusion images together with a radiologist. The improvement provided by SPECT/CT in the interpretation of SPECT data alone and any modification in patient management were recorded.
Fusion images improved SPECT interpretation in 23 cases, providing precise anatomical localisation of increased tracer uptake in 20 cases and disease exclusion in sites of physiological uptake in 5. In 10 patients, SPECT/CT allowed definition of the functional significance of lesions detected by diagnostic CT. SPECT/CT data modified clinical management in 14 cases by changing the diagnostic approach in 8 and the therapeutic modality in 6.
Our study demonstrates that image fusion is clearly superior to SPECT alone, allowing precise localisation of lesions and reducing false-positive results.

Keywords
Adult, Aged, Aged, 80 and over, False Positive Reactions, Female, Humans, Indium Radioisotopes, Male, Middle Aged, Neuroendocrine Tumors/diagnostic imaging, Octreotide/analogs & derivatives, Pentetic Acid/analogs & derivatives, Radiopharmaceuticals, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon/instrumentation, Tomography, Emission-Computed, Single-Photon/methods, Tomography, X-Ray Computed/methods
Pubmed
Web of science
Create date
20/08/2017 21:21
Last modification date
20/08/2019 12:23
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