Developmental trajectories of executive functions in 22q11.2 deletion syndrome

Details

Serval ID
serval:BIB_016B11DB20DC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Developmental trajectories of executive functions in 22q11.2 deletion syndrome
Journal
Journal of Neurodevelopmental Disorders
Author(s)
Maeder J., Schneider M., Bostelmann M., Debbané M., Glaser B., Menghetti S., Schaer M., Eliez S.
ISSN
1866-1947 (Print)
1866-1955 (Electronic)
ISSN-L
1866-1947
Publication state
Published
Issued date
2016
Volume
8
Pages
10
Language
english
Notes
Publication types: Journal ArticlePublication Status: epublish
Abstract
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is a genetic disorder associated with a specific cognitive profile. Higher-order cognitive skills like executive functions (EF) are reported as a relative weakness in this population. The present study aimed to delineate the developmental trajectories of multiple EF domains in a longitudinal sample using a broader age range than previous studies. Given the high incidence of psychotic symptoms in 22q11.2DS, we also compared the development of EF in participants with/without comorbid psychotic symptoms. Given the importance of EF in daily life, the third aim of the study was to characterize the link between EF and adaptive functioning.
METHODS: The sample consisted of 95 individuals with 22q11.2DS and 100 typically developing controls aged 6-26 years. A large proportion of the sample (55.38 %) had multiple time points available. Between-group differences in the developmental trajectories of three subdomains of EF (verbal fluency, working memory, and inhibition) were examined using mixed models regression analyses. Analyses were repeated comparing only the 22q11.2DS group based on the presence/absence of psychotic symptoms to investigate the influence of executive dysfunction on the emergence of psychotic symptoms. Hierarchical stepwise regression analyses were also conducted to investigate the predictive value of EF on adaptive functioning.
RESULTS: We observed lower performance on EF domains, as well as atypical development of working memory and verbal fluency. Participants who presented with negative symptoms exhibited different developmental trajectories of inhibition and working memory. Adaptive functioning level was not significantly predicted by EF scores.
CONCLUSIONS: The present study highlighted domain-specific atypical trajectories of EF in individuals with 22q11.DS and explored the link with psychotic symptoms. However, no relation between EF and adaptive functioning was observed.
Pubmed
Web of science
Open Access
Yes
Create date
03/11/2016 17:24
Last modification date
20/08/2019 12:23
Usage data