Differential regulation of RNA polymerase III genes during liver regeneration.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_014840C5C9E3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Differential regulation of RNA polymerase III genes during liver regeneration.
Journal
Nucleic Acids Research
Author(s)
Yeganeh M., Praz V., Carmeli C., Villeneuve D., Rib L., Guex N., Herr W., Delorenzi M., Hernandez N.
Working group(s)
CycliX consortium
Contributor(s)
Hernandez N., Delorenzi M., Deplancke B., Desvergne B., Guex N., Herr W., Naef F., Rougemont J., Schibler U., Andersin T., Cousin P., Gilardi F., Gos P., Lammers F., Lopes M., Mange F., Minocha S., Raghav S., Villeneuve D., Fabbretti R., Vlegel V., Xenarios I., Migliavacca E., Praz V., David F., Jarosz Y., Kuznetsov D., Liechti R., Martin O., Delafontaine J., Cajan J., Carmeli C., Gustafson K., Krier I., Leleu M., Molina N., Naldi A., Rib L., Sobel J., Symul L., Bounova G., Jacquet P.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
28/02/2019
Peer-reviewed
Oui
Volume
47
Number
4
Pages
1786-1796
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcription. Our results broadly define a class of genes close to H3K4me3 and Pol II peaks, whose Pol III occupancy is high and stable, and another class, distant from Pol II peaks, whose Pol III occupancy strongly increases after partial hepatectomy. Pol III regulation in the liver thus entails both highly expressed housekeeping genes and genes whose expression can adapt to increased demand.
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2019 11:49
Last modification date
20/08/2019 13:23
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