Multi-phase post-mortem CT angiography: development of a standardized protocol.

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Serval ID
serval:BIB_014784FE1425
Type
Article: article from journal or magazin.
Collection
Publications
Title
Multi-phase post-mortem CT angiography: development of a standardized protocol.
Journal
International Journal of Legal Medicine
Author(s)
Grabherr S., Doenz F., Steger B., Dirnhofer R., Dominguez A., Sollberger B., Gygax E., Rizzo E., Chevallier C., Meuli R., Mangin P.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
125
Number
6
Pages
791-802
Language
english
Abstract
The objective of this work was to develop an easily applicable technique and a standardized protocol for high-quality post-mortem angiography. This protocol should (1) increase the radiological interpretation by decreasing artifacts due to the perfusion and by reaching a complete filling of the vascular system and (2) ease and standardize the execution of the examination. To this aim, 45 human corpses were investigated by post-mortem computed tomography (CT) angiography using different perfusion protocols, a modified heart-lung machine and a new contrast agent mixture, specifically developed for post-mortem investigations. The quality of the CT angiographies was evaluated radiologically by observing the filling of the vascular system and assessing the interpretability of the resulting images and by comparing radiological diagnoses to conventional autopsy conclusions. Post-mortem angiography yielded satisfactory results provided that the volumes of the injected contrast agent mixture were high enough to completely fill the vascular system. In order to avoid artifacts due to the post-mortem perfusion, a minimum of three angiographic phases and one native scan had to be performed. These findings were taken into account to develop a protocol for quality post-mortem CT angiography that minimizes the risk of radiological misinterpretation. The proposed protocol is easy applicable in a standardized way and yields high-quality radiologically interpretable visualization of the vascular system in post-mortem investigations.
Pubmed
Web of science
Open Access
Yes
Create date
06/12/2010 16:50
Last modification date
01/10/2019 6:16
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