Statistical parametric mapping of 5-HT1A receptor binding in temporal lobe epilepsy with hippocampal ictal onset on intracranial EEG

Details

Serval ID
serval:BIB_0121B01539AB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Statistical parametric mapping of 5-HT1A receptor binding in temporal lobe epilepsy with hippocampal ictal onset on intracranial EEG
Journal
Neuroimage
Author(s)
Merlet I., Ryvlin P., Costes N., Dufournel D., Isnard J., Faillenot I., Ostrowsky K., Lavenne F., Le Bars D., Mauguiere F.
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Publication state
Published
Issued date
06/2004
Volume
22
Number
2
Pages
886-96
Language
english
Notes
Merlet, Isabelle
Ryvlin, Philippe
Costes, Nicolas
Dufournel, Damien
Isnard, Jean
Faillenot, Isabelle
Ostrowsky, Karine
Lavenne, Franck
Le Bars, Didier
Mauguiere, Francois
eng
Research Support, Non-U.S. Gov't
Neuroimage. 2004 Jun;22(2):886-96. doi: 10.1016/j.neuroimage.2004.02.014.
Abstract
Experimental data in animals show that 5-HT(1A) receptors are predominantly located in limbic areas and suggest that serotonin, via these receptors, mediates an antiepileptic and anticonvulsant effect. In this PET study, we used an antagonist of the 5-HT(1A) receptor, [(18)F]MPPF, to assess the extent of 5-HT(1A) receptor binding changes in a group of seven temporal lobe epilepsy (TLE) patients with hippocampal ictal onset demonstrated by intracerebral EEG recording. On the basis of MRI-measured hippocampal volumes (HV), patients were classified into "normal HV" or "hippocampal atrophy" (HA). Voxel-based analyses (SPM99) were performed to objectively assess the differences in [(18)F]MPPF binding potential (BP) between patients (taken as a group or as individuals) and a database of 48 controls subjects. In the full group of patients, a significant decreased BP was detected ipsilateral to the epileptogenic zone in the hippocampus, temporal pole, insula, and temporal neocortex. This result was confirmed in the subgroup of patients with HA. In patients with normal HV, the BP decrease was restricted to the temporal pole. TLE patients also demonstrated an increased BP in various regions contralateral to the epileptogenic zone. These data suggest that in TLE patients with hippocampal seizure onset, the decrease in 5-HT(1A) receptor binding partly reflects hippocampal neuronal loss, but is also observed in various regions involved in temporo-limbic epileptogenic networks that appeared normal on MRI. Further studies are warranted to evaluate the clinical usefulness of [(18)F]MPPF-PET as compared to other established PET tracers in drug resistant TLE.
Keywords
Adult, Anticonvulsants/therapeutic use, Brain Mapping/*methods, *Electroencephalography, Epilepsy, Temporal Lobe/diagnostic imaging/*metabolism, Female, Fluorine Radioisotopes, Hippocampus/diagnostic imaging/*metabolism/pathology, Humans, Male, Middle Aged, Models, Neurological, Models, Statistical, Receptor, Serotonin, 5-HT1A/*physiology, Tomography, Emission-Computed
Pubmed
Create date
29/11/2018 12:36
Last modification date
20/08/2019 12:23
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