Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring.

Details

Serval ID
serval:BIB_010F6ED50756
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring.
Journal
Nature Chemical Biology
Author(s)
Griss R., Schena A., Reymond L., Patiny L., Werner D., Tinberg C.E., Baker D., Johnsson K.
ISSN
1552-4469 (Electronic)
ISSN-L
1552-4450
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
10
Number
7
Pages
598-603
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish PDF : Article
Abstract
For many drugs, finding the balance between efficacy and toxicity requires monitoring their concentrations in the patient's blood. Quantifying drug levels at the bedside or at home would have advantages in terms of therapeutic outcome and convenience, but current techniques require the setting of a diagnostic laboratory. We have developed semisynthetic bioluminescent sensors that permit precise measurements of drug concentrations in patient samples by spotting minimal volumes on paper and recording the signal using a simple point-and-shoot camera. Our sensors have a modular design consisting of a protein-based and a synthetic part and can be engineered to selectively recognize a wide range of drugs, including immunosuppressants, antiepileptics, anticancer agents and antiarrhythmics. This low-cost point-of-care method could make therapies safer, increase the convenience of doctors and patients and make therapeutic drug monitoring available in regions with poor infrastructure.
Pubmed
Web of science
Create date
27/07/2014 15:03
Last modification date
20/08/2019 12:23
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