Quantitative magnetization transfer in in vivo healthy human skeletal muscle at 3 T.

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State: Serval
Version: author
Serval ID
serval:BIB_00F6FB867684
Type
Article: article from journal or magazin.
Collection
Publications
Title
Quantitative magnetization transfer in in vivo healthy human skeletal muscle at 3 T.
Journal
Magnetic Resonance in Medicine
Author(s)
Sinclair C.D., Samson R.S., Thomas D.L., Weiskopf N., Lutti A., Thornton J.S., Golay X.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
2010
Volume
64
Number
6
Pages
1739-1748
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
The value of quantitative MR methods as potential biomarkers in neuromuscular disease is being increasingly recognized. Previous studies of the magnetization transfer ratio have demonstrated sensitivity to muscle disease. The aim of this work was to investigate quantitative magnetization transfer imaging of skeletal muscle in healthy subjects at 3 T to evaluate its potential use in pathological muscle. The lower limb of 10 subjects was imaged using a 3D fast low-angle shot acquisition with variable magnetization transfer saturation pulse frequencies and amplitudes. The data were analyzed with an established quantitative two-pool model of magnetization transfer. T(1) and B(1) amplitude of excitation radiofrequency field maps were acquired and used as inputs to the quantitative magnetization transfer model, allowing properties of the free and restricted proton pools in muscle to be evaluated in seven different muscles in a region of interest analysis. The average restricted pool T(2) relaxation time was found to be 5.9 ± 0.2 μs in the soleus muscle and the restricted proton pool fraction was 8 ± 1%. Quantitative magnetization transfer imaging of muscle offers potential new biomarkers in muscle disease within a clinically feasible scan time.
Keywords
Adult, Female, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Leg, Magnetic Resonance Imaging/methods, Male, Middle Aged, Muscle, Skeletal/physiology
Pubmed
Web of science
Open Access
Yes
Create date
08/07/2013 10:22
Last modification date
08/05/2019 13:40
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