Early revascularization is beneficial across all ages and a wide spectrum of cardiogenic shock severity: A pooled analysis of trials

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_00EE435F75E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early revascularization is beneficial across all ages and a wide spectrum of cardiogenic shock severity: A pooled analysis of trials
Journal
Acute Cardiac Care
Author(s)
Jeger R.V., Urban P., Harkness S.M., Tseng C.H., Stauffer J.C., Lejemtel T.H., Sleeper L.A., Pfisterer M.E., Hochman J.S.
ISSN
1748-2941 (Print)
1748-295X (Electronic)
ISSN-L
1748-2941
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
13
Number
1
Pages
14-20
Language
english
Notes
Publication types: Article ; research-article Identifiant PubMed Central: PMC4224032
Abstract
BACKGROUND: A pooled analysis in cardiogenic shock due to acute coronary syndromes is desirable to assess the effect of early revascularization (ERV) across all ages and a wide spectrum of disease severity.
METHODS: Only two randomized controlled trials (RCT), i.e. SMASH and SHOCK, met the inclusion criteria and were combined for a pooled analysis using individual patient data (n = 348).
RESULTS: SMASH patients (n = 54, 16%) had more severe disease than SHOCK patients (n = 294, 84%). After adjustment for age, anoxic brain damage, non-inferior myocardial infarction, prior coronary artery bypass graft surgery, renal failure, systolic blood pressure, and selection for coronary angiography, one-year mortality was similar (relative risk SHOCK versus SMASH 0.87, 95% CI: 0.61-1.25). Relative risk of one-year death for ERV versus initial medical stabilization was 0.82 (95% CI: 0.70-0.96). There was no significant difference in the treatment effect by age (≤75 years relative risk at one year 0.79, 95% CI: 0.63-0.99; > 75 years relative risk at one year 0.93, 95% CI: 0.56-1.53; interaction P = 0.10).
CONCLUSIONS: Only two RCT have been published emphasizing the difficulty of enrolling critically ill patients. Despite large differences in shock severity, ERV benefit is similar across all ages and not significantly different for the elderly.
Keywords
Myocardial Infarction/complications, Shock, Cardiogenic/etiology, Shock, Cardiogenic/mortality, Shock, Cardiogenic/surgery
Pubmed
Open Access
Yes
Create date
11/07/2016 10:04
Last modification date
20/08/2019 12:23
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