Retinal pigment epithelium tears after intravitreal injection of ranibizumab for predominantly classic neovascular membranes secondary to age-related macular degeneration.

Details

Serval ID
serval:BIB_00DF6E6969CB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Retinal pigment epithelium tears after intravitreal injection of ranibizumab for predominantly classic neovascular membranes secondary to age-related macular degeneration.
Journal
Acta Ophthalmologica
Author(s)
Konstantinidis L., Ambresin A., Zografos L., Mantel I.
ISSN
1755-3768[electronic], 1755-375X[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
88
Number
7
Pages
736-741
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
PURPOSE: Retinal pigment epithelium (RPE) tear is an extremely rare complication in patients with classic neovascular membranes without RPE detachment. We evaluate their incidence and functional outcome following treatment with intravitreal ranibizumab. METHODS: Observational study of 72 consecutive patients (74 eyes) treated at Jules Gonin University Eye Hospital, Lausanne, with intravitreal ranibizumab 0.5 mg for classic choroidal neovascularization (CNV) between March 2006 and February 2008. Best-corrected visual acuity (BCVA), fundus examination and optical coherence tomography were recorded monthly; fluorescein angiography was performed at baseline and repeated at least every 3 months. RESULTS: RPE tears occurred in four (5.4%) eyes temporal to the fovea, after a mean of four injections (range 3-6). Mean baseline BCVA was 0.25 decimal equivalent (logMAR 0.67) and improved despite the RPE tear to 0.6 decimal equivalent (logMAR 0.22). CONCLUSION: RPE tears following intravitreal ranibizumab injections for classic CNV can occur in about 5% of patients, even in the absence of baseline RPE detachment. Nevertheless, vision may improve provided the fovea is not involved.
Pubmed
Web of science
Open Access
Yes
Create date
12/11/2010 14:40
Last modification date
20/08/2019 12:23
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