Long-term topiramate treatment of psychotropic drug-induced weight gain: a retrospective chart review

Details

Serval ID
serval:BIB_00A3BF35018E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term topiramate treatment of psychotropic drug-induced weight gain: a retrospective chart review
Journal
General Hospital Psychiatry
Author(s)
Khazaal Yasser, Chatton Anne, Rusca Manon, Preisig Martin, Zullino Daniele
ISSN
0163-8343
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
29
Number
5
Pages
446-449
Language
english
Notes
SAPHIRID:63323
Abstract
OBJECTIVE: The objective of this study was to determine the efficacy and tolerability of long-term topiramate treatment of psychotropic drug-induced weight gain. METHOD: We conducted a retrospective review of the charts of patients treated with add-on topiramate in order to control weight gain induced by psychotropic drugs (antipsychotic drugs, lithium or valproate). RESULTS: The case series consisted of 100 patients. The mean final dose of topiramate was 186.8+/-138.3 mg/day, whereas the median dose was 200 mg/day for a total treatment duration of 41+/-38 weeks. Adverse events led to topiramate discontinuation in 22% of the sample. A significant reduction in body mass index was observed between the first and last measures, from 29.7+/-3.6 to 28+/-3.3 (t=5.82, P<.0005). The reduction in body mass index was greater in patients treated with antipsychotic drugs than in those treated with lithium or valproate alone. No difference was found between subjects with and those without comorbid active substance abuse or dependence. CONCLUSIONS: In this retrospective case series, topiramate was found to be effective in reversing weight gain associated with antipsychotic drugs, lithium or valproate. Tolerability of topiramate was an issue in some patients.
Pubmed
Web of science
Create date
13/03/2008 8:39
Last modification date
20/08/2019 12:22
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