Treatment in early psychosis with N-acetyl-cysteine for 6 months improves low-level auditory processing: Pilot study.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_00A3B9194A8F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment in early psychosis with N-acetyl-cysteine for 6 months improves low-level auditory processing: Pilot study.
Journal
Schizophrenia research
Author(s)
Retsa C., Knebel J.F., Geiser E., Ferrari C., Jenni R., Fournier M., Alameda L., Baumann P.S., Clarke S., Conus P., Do K.Q., Murray M.M.
ISSN
1573-2509 (Electronic)
ISSN-L
0920-9964
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
191
Pages
80-86
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Sensory impairments constitute core dysfunctions in schizophrenia. In the auditory modality, impaired mismatch negativity (MMN) has been observed in chronic schizophrenia and may reflect N-methyl-d-aspartate (NMDA) hypo-function, consistent with models of schizophrenia based on oxidative stress. Moreover, a recent study demonstrated deficits in the N100 component of the auditory evoked potential (AEP) in early psychosis patients. Previous work has shown that add-on administration of the glutathione precursor N-acetyl-cysteine (NAC) improves the MMN and clinical symptoms in chronic schizophrenia. To date, it remains unknown whether NAC also improves general low-level auditory processing and if its efficacy would extend to early-phase psychosis. We addressed these issues with a randomized, double-blind study of a small sample (N=15) of early psychosis (EP) patients and 18 healthy controls from whom AEPs were recorded during an active, auditory oddball task. Patients were recorded twice: once prior to NAC/placebo administration and once after six months of treatment. The N100 component was significantly smaller in patients before NAC administration versus controls. Critically, NAC administration improved this AEP deficit. Source estimations revealed increased activity in the left temporo-parietal lobe in patients after NAC administration. Overall, the data from this pilot study, which call for replication in a larger sample, indicate that NAC improves low-level auditory processing in early psychosis.
Keywords
Acetylcysteine/pharmacology, Acetylcysteine/therapeutic use, Acoustic Stimulation, Adult, Antipsychotic Agents/pharmacology, Antipsychotic Agents/therapeutic use, Contingent Negative Variation/drug effects, Double-Blind Method, Electroencephalography, Evoked Potentials, Auditory/drug effects, Female, Follow-Up Studies, Humans, Male, Pilot Projects, Psychotic Disorders/drug therapy, Young Adult, Auditory, Auditory evoked potential, Glutathione, Mismatch negativity, N-acetyl-cysteine, Redox
Pubmed
Web of science
Create date
08/08/2017 8:09
Last modification date
20/08/2019 12:22
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