Recent changes in lifestyle have considerably reduced the loads that joints have to bear through occupational stresses. It is now essentially during leisure time that most people use somewhat intensely their locomotive systems, mostly as sustained bouts of physical exercise. The physician is therefore led to examining critically these sports activities and their consequences. One has to be aware of the fact that some sports may bring about an articular overuse, partly through trauma and partly through microtrauma. Nevertheless, when reviewing recent literature on the implied relation between exercise and degenerative joint disease, one is amazed in observing how contradictory the current opinions are. This article intends to be both a review and a synthesis of the various factors which are commonly accepted as playing a role in the etiology of degenerative joint disease consecutive to exercise. We take into account by the same token the well-known advantages of physical activity such as prevention of cardiovascular disease and atherosclerosis, the enhancement of psychic well-being and the delaying of the onset of ageing. Thus, knowing which sports may promote degenerative joint disease under given conditions, the physician will be able to counsel people with an identified proneness to joint disease into undertaking more healthful physical workouts.