Tubulointerstitial nephritis and uveitis syndrome: a systematic review.

Details

Serval ID
serval:BIB_009D997A5A1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Journal
Nephrology, dialysis, transplantation
Author(s)
Regusci A., Lava SAG, Milani G.P., Bianchetti M.G., Simonetti G.D., Vanoni F.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Publication state
Published
Issued date
25/04/2022
Peer-reviewed
Oui
Volume
37
Number
5
Pages
876-886
Language
english
Notes
Publication types: Journal Article ; Systematic Review
Publication Status: ppublish
Abstract
Tubulointerstitial nephritis and uveitis (TINU) syndrome is defined as the occurrence of tubulointerstitial nephritis (TIN) and uveitis in the absence of other systemic diseases. The most comprehensive review on this condition was published in 2001.
We conducted a systematic review of the literature for cases of TINU syndrome. MEDLINE and Embase databases were screened. Full-length articles or letters reporting cases with both TIN and uveitis were selected. We investigated differences between males and females and paediatric and adult cases. Multivariate analysis was performed to identify potential risk factors for chronic kidney disease (CKD) development.
A total of 233 articles reporting 592 TINU cases were retained for the analysis. The median age of the included subjects was 17 years (interquartile range 13-46) with a female predominance (65%). Uveitis most frequently (52%) followed renal disease and was mostly anterior (65%) and bilateral (88%). Children tended to have more ocular relapses, while they were slightly less likely than adults to suffer from acute kidney injury and to develop CKD. Adult age as well as posterior or panuveitis were associated with an increased risk of developing CKD.
TINU affects both children and adults, with some differences between these two categories. Adult age and the presence of a posterior uveitis or panuveitis appear to be associated with the development of CKD.
Keywords
Adolescent, Adult, Child, Female, Humans, Male, Nephritis, Interstitial/epidemiology, Nephritis, Interstitial/etiology, Panuveitis/complications, Renal Insufficiency, Chronic/complications, Tin, Uveitis/diagnosis, Uveitis/epidemiology, Uveitis/etiology, TINU, systematic review, tubulointerstitial nephritis, uveitis
Pubmed
Create date
22/02/2021 13:54
Last modification date
04/05/2022 5:35
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