Tubulointerstitial nephritis and uveitis syndrome: a systematic review.

Details

Serval ID
serval:BIB_009D997A5A1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Journal
Nephrology, dialysis, transplantation
Author(s)
Regusci A., Lava SAG, Milani G.P., Bianchetti M.G., Simonetti G.D., Vanoni F.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Tubulointerstitial nephritis and uveitis (TINU) is defined as the occurrence of tubulointerstitial nephritis and uveitis in the absence of other systemic diseases. The most comprehensive review on this condition was published in 2001.
We conducted a systematic review of the literature on cases of TINU syndrome. Medline an EMBASE databases were screened. Full-length articles or letters reporting cases with both tubulointerstitial nephritis and uveitis were selected. We investigated differences between males/females and pediatric and adult cases. Multivariate analysis was performed to identify potential risk factors for chronic kidney disease development.
233 articles reporting 592 TINU cases were retained for analysis. The median age of the included subjects was 17 (interquartile range 13-46) years, with a female predominance (65%). Uveitis most frequently (52%) followed renal disease, and was mostly anterior (65%) and bilateral (88%). Children tended to have more ocular relapses while they were slightly less likely than adults to suffer from acute kidney injury and to develop chronic kidney disease. Adult age, as well as posterior or panuveitis, were associated with an increased risk of developing chronic kidney disease.
TINU affects both children and adults, with some differences between these two categories. Adult age and the presence of a posterior uveitis or panuveitis appear to be associated with the development of chronic kidney disease.
Keywords
systematic review, TINU, tubulointerstitial nephritis, uveitis
Pubmed
Create date
22/02/2021 14:54
Last modification date
23/02/2021 7:26
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