Fatigue in inflammatory bowel disease and its impact on daily activities.

Details

Serval ID
serval:BIB_00961F0DB62B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fatigue in inflammatory bowel disease and its impact on daily activities.
Journal
Alimentary pharmacology & therapeutics
Author(s)
Schreiner P., Rossel J.B., Biedermann L., Valko P.O., Baumann C.R., Greuter T., Scharl M., Vavricka S.R., Pittet V., Juillerat P., Rogler G., von Känel R., Misselwitz B.
Working group(s)
Swiss IBD Cohort Study Group
Contributor(s)
Abdelrahman K., Ademi G., Aepli P., Thomas A., Anderegg C., Antonino A.T., Archanioti E., Arrigoni E., Aslan N., Bakker de Jong D., Balsiger B., Bastürk P., Bauerfeind P., Becocci A., Bengoa J.M., Biedermann L., Binek J., Blattmann M., Boehm S., Boldanova T., Borovicka J., Braegger C.P., Brand S., Bravo F., Brügger L., Brunner S., Bühr P., Burk S., Burri E., Butter M., Buyse S., Cao D.T., Carstens O., Criblez D.H., D'Angelo F., Saussure P., Degen L., Delarive J., Doerig C., Dora B., Drerup S., Ducrey C., El-Wafa A., Engelmann M., Erdmann-Voisin A., Felley C., Fliegner M., Fraga M., Franc Y., Frei P., Frei R., Fried M., Froehlich F., Furlano R.I., Garzoni L., Geyer M., Girardin M., Golay D., Good I., Bigler U.G., Godat S., Greuter T., Gysi B., Haarer J., Halama M., Haldemann J., Heer P., Heimgartner B., Helbling B., Hengstler P., Herzog D., Hess C., Hessler R., Heyland K., Hinterleitner T., Hirschi C., Hruz P., Juillerat P., Kapoglou I., Kayser S., Keller C., Khalid-de Bakker C., Knellwolf C., Knoblauch C., Köhler H., Koller R., Krieger C., Künzler P., Kusche R., Lehmann F.S., Macpherson A., Maillard M.H., Manz M., Martinho M., Meier R., Meyenberger C., Meyer P., Michetti P., Misselwitz B., Morell B., Mosler P., Moschouri E., Mottet C., Müller C., Müllhaupt B., Musso L., Neagu M., Nichita C., Niess J., Nydegger A., Obialo N., Oropesa C., Peter U., Peternac D., Petit L.M., Pittet V., Pohl D., Porzner M., Preissler C., Raschle N., Rentsch R., Restellini S., Richterich J.P., Riedmüller S., Risti B., Ritz M.A., Rogler G., Röhrich N., Rossel J.B., Roth R., Rueger V., Sagmeister M., Saner G., Sarraj R., Sauter B., Sawatzki M., Scharl M., Scharl S., Schelling M., Schibli S., Schlauri H., Schluckebier D., Schmid D., Schmid S., Schnegg J.F., Schoepfer A., Schreiner P., Seibold F., Seirafi M., Semadeni G.M., Senning A., Sokollik C., Sommer J., Spalinger J., Spangenberger H., Stadler P., Staub P., Staudenmann D., Stenz V., Steuerwald M., Straumann A., Stulz A., Sulz M., Tempia-Caliera M., Thorens J., Truninger K., Tutuian R., Urfer P., Vavricka S., Viani F., Vinzens F., Vögtlin J., Von Känel R., Vouillamoz D., Vulliamy R., Vullièmoz M., Wiesel P., Wiest R., Wöhrle S., Yilmaz B., Zamora S., Zander S., Zeitz J., Zimmermann D.
ISSN
1365-2036 (Electronic)
ISSN-L
0269-2813
Publication state
Published
Issued date
01/2021
Peer-reviewed
Oui
Volume
53
Number
1
Pages
138-149
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Fatigue is a common symptom of chronic inflammation, including inflammatory bowel disease (IBD), resulting in significant impairment in quality of life.
To identify the prevalence of fatigue in a large IBD cohort compared to the general population, address risk factors, and evaluate its impact on daily life.
We evaluated 1208 IBD patients from the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) and 414 healthy controls. Significant fatigue was defined as a visual analogue scale (VAS-F, range 0-10) score ≥ 4. Secondary endpoints were severity of fatigue and its impact on daily activities with the Fatigue Severity Scale (FSS), with a score ≥ 4 indicative of fatigue. Demographic, IBD-related and psychiatric symptoms were assessed with a multivariate analysis of variance (MANOVA) model optimised for prediction of VAS-F (primary outcome) and FSS scores.
Overall, 672 IBD patients (55.6%) reported significant fatigue compared to 145 (35%) controls (OR 2.71; 95% CI 2.08-3.54; P < 0.001). In IBD, fatigue also significantly affected daily activities (FSS ≥ 4; 405 (33.5%) IBD patients vs 81 (19.6%) controls, P < 0.001). In the MANOVA model, fatigue levels were associated with female gender (coefficient 0.839; 0.556 - 1.123; P < 0.001), younger age at diagnosis (-0.031 per year; -0.042- -0.019; P < 0.001), shorter disease duration (-0.036 per year; -0.050- -0.022; P < 0.001), nocturnal diarrhoea (0.718; 0.295-1.141; P = 0.001), low educational level (P = 0.034) and symptoms of depression and anxiety.
Fatigue is both more frequent and more severe in patients with IBD than in the general population.
Keywords
Anxiety, Cohort Studies, Fatigue/epidemiology, Fatigue/etiology, Female, Humans, Inflammatory Bowel Diseases/complications, Inflammatory Bowel Diseases/diagnosis, Inflammatory Bowel Diseases/epidemiology, Quality of Life, Severity of Illness Index, Surveys and Questionnaires
Pubmed
Web of science
Create date
23/11/2020 10:27
Last modification date
20/07/2021 10:24
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