Prognostic value positron emission tomography with [18F]fluoro-2-deoxy-D-glucose in the low-grade glioma.

Details

Serval ID
serval:BIB_008138BD3E43
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prognostic value positron emission tomography with [18F]fluoro-2-deoxy-D-glucose in the low-grade glioma.
Journal
Neurosurgery
Author(s)
De Witte O., Levivier M., Violon P., Salmon I., Damhaut P., Wikler D., Hildebrand J., Brotchi J., Goldman S.
ISSN
0148-396X (Print)
ISSN-L
0148-396X
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
39
Number
3
Pages
470-477
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECTIVE: The natural history of the supratentorial low-grade glioma (LGG) of the adult is variable, and its malignant transformation is hardly predictable. Because positron emission tomography with [18F]fluoro-2-deoxy-D-glucose (FDG) has prognostic value in high-grade gliomas, this study was designed to search for a possible relationship between glucose metabolism and risk of malignant evolution in LGGs.
METHODS: Positron emission tomography with FDG was performed in 28 patients with LGGs (22 at the time of diagnosis and 6 after the diagnosis). A metabolic grading system based on the visual inspection of the positron emission tomographic images was used.
RESULTS: In 19 patients, no area of FDG uptake higher than in the white matter was detected (metabolic Grade 1). All of those patients were alive at the end of the follow-up period. Only one of the patients presented a histological modification 7 months after the diagnosis. Nine patients presented areas of increased FDG uptake (metabolic Grade 2 or 3). Those areas were found in the tumor area in eight patients and in an area of radionecrosis in one. Of the nine patients with FDG "hot spots," six died, two had recurrence but were alive at the end of the follow-up period, and the patient with radionecrosis had no signs of recurrence.
CONCLUSIONS: The presence of areas of increased FDG uptake in a histologically proven LGG predicts, in most cases, a deleterious evolution. This metabolic feature, detectable with a noninvasive procedure, may provide a clue to cellular changes, announcing malignant transformation in a tumor that retains the histological features of an LGG. Protocols with aggressive therapeutic strategies in this situation should be considered for evaluation.
Keywords
Adolescent, Adult, Astrocytoma/mortality, Astrocytoma/radionuclide imaging, Biopsy, Blood Glucose/metabolism, Brain/pathology, Brain/radionuclide imaging, Brain Neoplasms/mortality, Brain Neoplasms/radionuclide imaging, Deoxyglucose/analogs & derivatives, Deoxyglucose/metabolism, Energy Metabolism/physiology, Female, Fluorodeoxyglucose F18, Ganglioglioma/mortality, Ganglioglioma/radionuclide imaging, Glioma/mortality, Glioma/radionuclide imaging, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/mortality, Neoplasm Recurrence, Local/radionuclide imaging, Oligodendroglioma/mortality, Oligodendroglioma/radionuclide imaging, Prognosis, Survival Rate, Tomography, Emission-Computed
Pubmed
Web of science
Create date
20/01/2008 17:35
Last modification date
20/08/2019 12:22
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