Klebsiella pneumoniae OmpR facilitates lung infection through transcriptional regulation of key virulence factors.

Details

Serval ID
serval:BIB_003C384BFE4A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Klebsiella pneumoniae OmpR facilitates lung infection through transcriptional regulation of key virulence factors.
Journal
Microbiology spectrum
Author(s)
Janssen A.B., de Bakker V., Aprianto R., Trebosc V., Kemmer C., Pieren M., Veening J-W
ISSN
2165-0497 (Electronic)
ISSN-L
2165-0497
Publication state
Published
Issued date
11/01/2024
Peer-reviewed
Oui
Volume
12
Number
1
Pages
e0396623
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Bacteria use two-component regulatory systems (TCSs) to adapt to changes in their environment by changing their gene expression. In this study, we show that the EnvZ/OmpR TCS of the clinically relevant opportunistic pathogen Klebsiella pneumoniae plays an important role in successfully establishing lung infection and virulence. In addition, we elucidate the K. pneumoniae OmpR regulon within the host. This work suggests that K. pneumoniae OmpR might be a promising target for innovative anti-infectives.
Keywords
Klebsiella pneumoniae, OmpR, dual RNA-seq, epithelial cells, host-pathogen interaction, infection
Pubmed
Web of science
Open Access
Yes
Create date
19/12/2023 8:33
Last modification date
16/01/2024 7:12
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