Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice.

Details

Serval ID
serval:BIB_001D7D0300C2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice.
Journal
Bone
Author(s)
Gaudin-Audrain C., Irwin N., Mansur S., Flatt P.R., Thorens B., Baslé M., Chappard D., Mabilleau G.
ISSN
1873-2763 (Electronic)
ISSN-L
1873-2763
Publication state
Published
Issued date
2013
Volume
53
Number
1
Pages
221-230
Language
english
Abstract
A role for the gastro-intestinal tract in controlling bone remodeling is suspected since serum levels of bone remodeling markers are affected rapidly after a meal. Glucose-dependent insulinotropic polypeptide (GIP) represents a suitable candidate in mediating this effect. The aim of the present study was to investigate the effect of total inhibition of GIP signaling on trabecular bone volume, microarchitecture and quality. We used GIP receptor (GIPR) knockout mice and investigated trabecular bone volume and microarchitecture by microCT and histomorphometry. GIPR-deficient animals at 16 weeks of age presented with a significant (20%) increase in trabecular bone mass accompanied by an increase (17%) in trabecular number. In addition, the number of osteoclasts and bone formation rate was significantly reduced and augmented, respectively in these animals when compared with wild-type littermates. These modifications of trabecular bone microarchitecture are linked to a remodeling in the expression pattern of adipokines in the GIPR-deficient mice. On the other hand, despite significant enhancement in bone volume, intrinsic mechanical properties of the bone matrix was reduced as well as the distribution of bone mineral density and the ratio of mature/immature collagen cross-links. Taken together, these results indicate an increase in trabecular bone volume in GIPR KO animals associated with a reduction in bone quality.
Keywords
Glucose-dependent insulinotropic polypeptide, Bone microarchitecture, Bone quality, Adipokine, Incretin
Pubmed
Web of science
Create date
17/01/2013 14:32
Last modification date
20/08/2019 13:22
Usage data