Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala.

Details

Serval ID
serval:BIB_00155BA2A291
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala.
Journal
Nature neuroscience
Author(s)
Abatis M., Perin R., Niu R., van den Burg E., Hegoburu C., Kim R., Okamura M., Bito H., Markram H., Stoop R.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
07/2024
Peer-reviewed
Oui
Volume
27
Number
7
Pages
1309-1317
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and whether it also plays a role in storing it are still largely unknown. Here, using ex vivo 12-patch-clamp and in vivo 32-electrode electrophysiological recordings in the LA of fear-conditioned rats, in combination with activity-dependent fluorescent and optogenetic tagging and recall, we identified a sparsely connected network between principal LA neurons that is organized in clusters. Fear conditioning specifically causes potentiation of synaptic connections between learning-recruited neurons. These findings of synaptic plasticity in an autoassociative excitatory network of the LA may suggest a basic principle through which a small number of pyramidal neurons could encode a large number of memories.
Keywords
Animals, Fear/physiology, Rats, Basolateral Nuclear Complex/physiology, Male, Neurons/physiology, Neuronal Plasticity/physiology, Optogenetics, Conditioning, Classical/physiology, Learning/physiology, Patch-Clamp Techniques, Synapses/physiology, Memory/physiology, Amygdala/physiology, Amygdala/cytology
Pubmed
Web of science
Open Access
Yes
Create date
17/06/2024 15:32
Last modification date
16/07/2024 7:09
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