Regulation of monocyte functional heterogeneity by miR-146a and Relb.

Détails de la publication Détails dans Serval
ID Serval serval:BIB_1785F1B65F2C
Type de publication
Article: article d'un périodique ou d'un magazine.
Collection Publications
Fonds UNIL/CHUV
Auteur(s) Etzrodt M., Cortez-Retamozo V., Newton A., Zhao J., Ng A., Wildgruber M., Romero P., Wurdinger T., Xavier R., Geissmann F., Meylan E., Nahrendorf M., Swirski F.K., Baltimore D., Weissleder R., Pittet M.J.
Titre Regulation of monocyte functional heterogeneity by miR-146a and Relb.
Périodique Cell Reports
Statut éditorial Publié
Année 2012
Volume 1
Numéro 4
Pages 317-324
Langue anglais
Note Publication types: Journal Article ; Research Support, N.I.H., ExtramuralPublication Status: ppublish
Résumé Monocytes serve as a central defense system against infection and injury but can also promote pathological inflammatory responses. Considering the evidence that monocytes exist in at least two subsets committed to divergent functions, we investigated whether distinct factors regulate the balance between monocyte subset responses in vivo. We identified a microRNA (miRNA), miR-146a, which is differentially regulated both in mouse (Ly-6C(hi)/Ly-6C(lo)) and human (CD14(hi)/CD14(lo)CD16(+)) monocyte subsets. The single miRNA controlled the amplitude of the Ly-6C(hi) monocyte response during inflammatory challenge whereas it did not affect Ly-6C(lo) cells. miR-146a-mediated regulation was cell-intrinsic and depended on Relb, a member of the noncanonical NF-κB/Rel family, which we identified as a direct miR-146a target. These observations not only provide mechanistic insights into the molecular events that regulate responses mediated by committed monocyte precursor populations but also identify targets for manipulating Ly-6C(hi) monocyte responses while sparing Ly-6Clo monocyte activity.
ISBN/ISSN 2211-1247 (Electronic)
URN urn:nbn:ch:serval-BIB_1785F1B65F2C2
OAI oai:serval.unil.ch:BIB_1785F1B65F2C
DOI 10.1016/j.celrep.2012.02.009
Référence externe Pubmed : 22545247
Référence externe Web of Science : 000309712000004
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Dernière modification 2012-12-10